Figure 2. Increased expression of senescence-associated p21, Pai-1 and angptl2 in the native aortic endothelium of 6-month old ATX compared to WT mice. mRNA expression of indicated genes was quantified in the native aortic endothelium of 6-mo WT and ATX mice (n=3). The average level of gene expression in 6-mo WT mice was arbitrarily set at 1. Data are expressed as mean±SEM. *: p<0.05 vs. WT mice.