Research Paper Volume 11, Issue 11 pp 3832—3850

Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Figure 2. Increased expression of senescence-associated p21, Pai-1 and angptl2 in the native aortic endothelium of 6-month old ATX compared to WT mice. mRNA expression of indicated genes was quantified in the native aortic endothelium of 6-mo WT and ATX mice (n=3). The average level of gene expression in 6-mo WT mice was arbitrarily set at 1. Data are expressed as mean±SEM. *: p<0.05 vs. WT mice.