Research Paper Volume 11, Issue 11 pp 3832—3850

Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Figure 4. Down-regulation of vascular angptl2 is anti-atherogenic. (A) Representative images of longitudinally open thoracic aortas showing atherosclerotic plaque, and (B) Quantification of thoracic aorta atheroma plaque area in 3 mo control (CTL 3-mo, n=6), 6-mo control (CTL 6-mo, n=12), 6-mo AAV1-shScramble (+ shSCR, n=11) and 6-mo AAV1-shAngptl2 (+ shAngptl2, n=12) ATX mice revealing white atheroma plaques at 6-mo. Data are mean±SEM. *: p<0.0001 vs. CTL 6-mo and shSCR; $: p<0.0001 vs. CTL 3-mo.