Research Paper Volume 11, Issue 11 pp 3832—3850

Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Figure 8. Down-regulation of vascular angptl2 is anti-atherogenic and promotes endothelial repair. (A) Increased expression of the progenitor marker Cd34 mRNA in the native aortic endothelium 4-week post-injection of shAngptl2 ATX mice. Data are mean±SEM. * : p<0.05 vs. shSCR group. The average gene expression levels in the shSCR group were arbitrarily set at 1. (B) Higher CD34 staining in the endothelium of 6-month old ATX mice 3 months post-injection of the AAV1-shAngptl2 compared to ATX mice injected with the scramble shRNA (shSCR). Data are mean±SEM. *: p<0.05 vs. shSCR. C) Representative images of CD34 immunostaining are shown.