Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Laurie Caland; Pauline Labbé; Maya Mamarbachi; Louis Villeneuve; Gerardo Ferbeyre; Pierre-Emmanuel Noly; Michel Carrier; Nathalie Thorin-Trescases; Éric Thorin

doi:doi:10.18632/aging.102020

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Research Paper Volume 11, Issue 11 pp 3832—3850

Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Figure 9. Association of vascular ANGPTL2, senescence and inflammation in IMA from atherosclerotic patients undergoing coronary artery by-pass surgery. Linear correlations between (A) ANGPTL2 and p21 mRNA expression, (B) ANGPTL2 and TNF-α, IL-8 and IL-6 mRNA expression and (C) p21 and TNF-α, IL-8 and IL-6 mRNA expression in IMA segments (n=26). Non-parametric Spearman correlation test was applied. Patient’s characteristics are described in Table S2.