Research Paper Volume 11, Issue 12 pp 3969—3992

AGTR1 promotes lymph node metastasis in breast cancer by upregulating CXCR4/SDF-1α and inducing cell migration and invasion

Figure 8. Schematic description of AGTR1-mediated signaling through CXCR4/SDF-1α, which regulates breast cancer migration and lymph node metastasis. AGTR1 enhances the level of SDF-1a in the lymph node, which attracts tumors that highly express CXCR4 cells. The mechanism of AGTR1-induced migration and invasion of tumor cells through upregulating CXCR4 and FAK/RhoA molecules.