Research Paper Volume 11, Issue 12 pp 4032—4049

Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation

Figure 11. Effects of QYFE on the activation of estrogen receptors (ER) α and ERβ in HEK293T cells. The effect of QYFE on estrogen receptors α and β activity in the transiently transfected HEK293T-ERα and HEK293T-ERβ cells was investigated by measuring reporter gene-coupled luciferase activity. ***P<0.001 compared to Con; #P<0.05, ##P<0.01, ###P<0.001 compared to 17β- estradiol or QYFE.