Research Paper Volume 11, Issue 12 pp 4032—4049

Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation

Figure 3. The effects of QYFE treatment on the histology of uterus, vagina and mammary gland in the OVX rats. Representative photomicrographs taken at 200-X magnification of uterine, 400-X magnification of vaginal and mammary gland sections in ovariectomized (OVX) rats. (AC) are the histology of the uterus, vagina and mammary gland, respectively in OVX rats. The treatment groups in OVX rats are shown: (I) Untreated ovariectomized (OVX) rat; (II) sham-operated rat; (III) OVX rat treated with estradiol valerate (EV); and OVX rat treated with (IV) 0.7 g/kg, (V) 1.4 g/kg, and (VI) 2.8 g/kg QYFE.