Research Paper Volume 11, Issue 12 pp 4050—4065

TRPM7 channel inhibition exacerbates pulmonary arterial hypertension through MEK/ERK pathway

Figure 7. TRPM7 inhibitor waixenicin A exacerbates hypoxia-induced PAH in vivo. (AD) Rats were exposed to hypoxia (10% O2) for 21 d or maintained under a normoxic condition, and concomitantly administrated with 200 mg/kg waixenicin A every 3 days. Each group includes 12 rats. The hemodynamic parameters including RV systolic pressure (RVSP) (A), and RV hypertrophy (RV/(LV+ septum (S)) (B) were measured. (C) Percentage of the medial wall thickness of pulmonary arteries. 20-70 μm in diameter. Data are mean ± SEM. n = 12. Unpaired Student’s t-test. **, P < 0.01 compared to vehicle control.