Research Paper Volume 11, Issue 12 pp 4107—4124
Grape seed proanthocyanidins ameliorate neuronal oxidative damage by inhibiting GSK-3β-dependent mitochondrial permeability transition pore opening in an experimental model of sporadic Alzheimer’s disease
Figure 3. GSPs inhibited STZ-induced Aβ accumulation and phosphorylation of tau in vivo. (A and B) Representative immunoblot bands for APP, Aβ, p-tau and tau in the cerebral cortex and hippocampus, respectively. (C–F) Quantification analysis of immunoblot bands. Protein expression levels were normalized to β-actin. *P < 0.05 vs Sham; #P < 0.05 vs STZ, n=4-6.