Research Paper Volume 11, Issue 12 pp 4107—4124

Grape seed proanthocyanidins ameliorate neuronal oxidative damage by inhibiting GSK-3β-dependent mitochondrial permeability transition pore opening in an experimental model of sporadic Alzheimer’s disease

Figure 5. GSPs inhibited STZ-induced mitochondria-associated apoptosis signaling pathway in vivo. (A and B), Representative immunoblot bands for Bcl-2, Bax, cleaved caspase-3 and caspase-3 in the cerebral cortex and hippocampus. (C-F), Quantification analysis of immunoblot bands. Protein expression levels were normalized to β-actin. *P < 0.05 vs Sham; #P < 0.05 vs STZ, n=4-6.