Research Paper Volume 11, Issue 12 pp 4145—4158

Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice

Figure 4. Increased senescence in murine ISCs after heavy ion radiation exposure. (A) Representative IF images showing increased p21 expression in ISCs from heavy ion radiation exposed mice. (B) Increased p19 expression in ISCs from heavy ion radiation exposed mice. (C) ISC sections immunofluorescently stained for Glb1 show increased staining in irradiated samples. (D) Representative IF images showing increased p16 levels in ISCs from heavy ion radiation exposed mice. Scale bar, 5 μm.