Research Paper Volume 11, Issue 12 pp 4145—4158

Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice


Figure 5. Senescence and SASP in ISCs after exposure to heavy ion radiation. (A) Representative IF images of ISCs co-stained for senescent markers Lamin 1B (red) and Glb1 (green) showing decreased expression of Lamin 1B in senescent cells. (B) Increased expression of SASP marker IL6 after heavy ion iron radiation exposure. Scale bars, 5 μm.