Research Paper Volume 11, Issue 12 pp 4145—4158

Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice

Figure 6. Acquisition of SASP by heavy ion radiation-induced senescent ISCs. ISC sections from control and irradiated mice were co-stained for SASP marker VEGF (green) and senescent marker Glb1 (red) showing acquisition of secretory phenotype by senescent cells after heavy ion radiation exposure. Scale bar, 5 μm.