Research Paper Volume 11, Issue 12 pp 4159—4182

Proteomics-based identification of different training adaptations of aged skeletal muscle following long-term high-intensity interval and moderate-intensity continuous training in aged rats

Figure 5. Proposed model of the mechanism by which HIIT improved skeletal muscle function in aged rats. HIIT protocols preserve skeletal muscle function by activating lysosomal degradation and improving mitochondrial OXPHOS via the ADP/ADPR1 axis, mediated by the AMPK pathway.