Research Paper Volume 11, Issue 12 pp 4216—4237

β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid

Figure 1. TCQA promoted hair regrowth in C3H mice skin. (A) The back skin of eight-weeks-old male C3H mice was shaved and treated daily with topical application of 1 wt% TCQA (1 g TCQA in 100 ml milli-Q water) and with milli-Q water (control) for 30 days. (B) The area of the new generated coat was measured by ImageJ. (C) Skin from treated area from TCQA-treated group and control group were cut at thickness of 10 µM and visualized under the microscope. *Statistically significant (P ≤0.05) difference between control and TCQA-treated group. **Statistically significant (P ≤0.01) difference between control and TCQA-treated mice.