Figure 2CD. Transcriptome changes induced by TCQA, 1235 genes were significantly selected: 435 were upregulated and 800 downregulated. (C) Hierarchical clustering of the genes altered after treatment with TCQA using Euclidean distance and average linkage algorithm of the TIGR Mev version 3.0.3 software (The Institute for Genomic Research, MD, USA). Horizontal stripes represent genes and columns represent control and TCQA. The significant fold change in gene expression is 2-fold change (control vs TCQA). (D) The volcano plot represents the regulated genes between the control and TCQA. The red color represents the upregulated genes, the green color the downregulated genes, and the grey color the unregulated genes. The expression of the genes above or below, left or right, the lines differed more than 2-fold change between the control and TCQA group.