Research Paper Volume 11, Issue 12 pp 4216—4237

β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid

Figure 5EF. TCQA stimulated β-catenin expression in human hair follicle dermal papilla cells (HFDPCs) (E) Cell proliferation of HFDPC was assessed after 48 h treatment with various concentrations of XAV939 (β-catenin inhibitor). (F) Gene expression expressions of CTNNB1 (β-catenin) after treatment with 10 µM XAV939 for 6 and 12 h, with 10 µM XAV939 for 6 and 12 h then with 10 µM TCQA for 6 h and 12 h (XAV939/TCQA), and finally with co-treatment of 10 µM XAV939 and 10 µM TCQA for 6 and 12 h (XAV939+TCQA). Results represent the mean ± SD of three independent experiments. *Statistically significant (P ≤0.05) difference between control and treated cells. **Statistically significant (P ≤0.01) difference between control and treated cells. ##Statistically significant (P ≤0.01) difference between Minox-treated cells and TCQA-treated cells.