Figure 2. The A allele is associated with a significant increase in plasma NFL (P<0.001), P value in the plot was computed from linear regression model after adjusting for age, diagnosis, and APOE4 status (A). Kaplan–Meier survival curves for the probability of clinical disease progression according to different rs16840041 genotypes. Numbers of individuals at risk at each time interval are shown in the table. Survival time was calculated as the interval from the initial baseline evaluation to the clinical disease progression. AG/AA genotype is associated with an increased risk of clinical disease progression (P = 0.006) (B).