Research Paper Volume 11, Issue 14 pp 4876—4889

LncRNA SLCO4A1-AS1 promotes colorectal cancer cell proliferation by enhancing autophagy via miR-508-3p/PARD3 axis

Figure 2. SLCO4A1-AS1 knockdown decreased autophagy in CRC cells. (A) Overexpressed SLCO4A1-AS1 was found after specific lentivirus transfection in LOVO and HCT116 cells; (B) SLCO4A1-AS1 was remarkedly suppressed after sh-SLCO4A1-AS1 transfection in HT29 and SW620 cells; (C, D) Increased or decreased autophagic vacuole numbers were found after SLCO4A1-AS1 overexpression or knockdown in LOVO and HCT116 cells by TEM. * P < 0.05, **P < 0.01 and ***P < 0.001.