Research Paper Volume 11, Issue 14 pp 4876—4889

LncRNA SLCO4A1-AS1 promotes colorectal cancer cell proliferation by enhancing autophagy via miR-508-3p/PARD3 axis

Figure 4. SLCO4A1-AS1 overexpression promoted CRC cell proliferation. (A) Up-regulation of SLCO4A1-AS1 promoted cell proliferation in LOVO cells by MTS assay. (B) SLCO4A1-AS1 overexpression enhanced cell proliferative rate in LOVO cells detected by colony formation assay. (C) EdU incorporation assays indicated the cell proliferation rate after SLCO4A1-AS1 overexpression or knockdown; (D) The ratio of S phase cells increased after overexpression of SLCO4A1-AS1 in LOVO cells. SLCO4A1-AS1 knockdown repressed S phase SW620 cells. (E) Apoptotic rate decreased after up-regulation of SLCO4A1-AS1 in LOVO cells. *P < 0.05