Research Paper Volume 11, Issue 14 pp 4890—4899

GCN-5/PGC-1α signaling is activated and associated with metabolism in cyclin E1-driven ovarian cancer

Figure 1. Cyclin E1-driven HGSOC shows metabolic alteration. Reproduced from TCGA, shown are (A) significantly enriched gene expressions (blue), amongst which included (B) significantly upregulated G6PC3, (C) functional annotation revealing significantly altered metabolic pathways and (D) correlations of expressions of CCNE1 and metabolic genes; In two CCNE1-amplified HGSOC cell lines, shown are silencing efficacy of (E) CDK2 and (F) GCN5; and expressions of (G) G6PC and (H) PGC-1α. (*P < 0.05; **P < 0.01)