Research Paper Volume 11, Issue 14 pp 4890—4899

GCN-5/PGC-1α signaling is activated and associated with metabolism in cyclin E1-driven ovarian cancer

Figure 2. GCN5/PGC-1α axis mediates metabolism in Cyclin E1-driven HGSOC. Shown are acetylation of PGC-1α by GCN5 silencing in (A) OVCAR-3 and (B) A2780 cells, and acetylation of PGC-1α and Rb by CDK2 silencing in (C) OVCAR-3 and (D) A2780 cells; Shown are (E) glucose consumption, (F) lactate secretion, (G) succinate dehydrogenase activity in cells with CDK and GCN5 silencing. (*P < 0.05; **P < 0.01)