Research Paper Volume 11, Issue 14 pp 4990—5007

Long noncoding RNA FALEC inhibits proliferation and metastasis of tongue squamous cell carcinoma by epigenetically silencing ECM1 through EZH2

Figure 1. FALEC is markedly downregulated in TSCC and predicts good prognosis. (A) Hierarchical clustering analysis of lncRNAs that were differentially expressed (fold change > 2; p < 0.05) in tongue squamous cell carcinoma (TSCC) and normal tissues in TCGA cohort. (B) Kaplan-Meier curves for OS of TSCC patients with high vs. low expression of FALEC in TCGA cohort. (C) The Sequencing result of FALEC expression in TSCC and normal tissues in TCGA cohort. (D) The Sequencing result of FALEC in TSCC tissues of different T classification and normal tissues. (E) The Sequencing result of FALEC in TSCC tissues of different Stage and normal tissues. (F) FALEC expression was analyzed in GSE51700. (G) FALEC expression was detected in TSCC tissues and paired normal adjacent tissues. (H) Relative FALEC expression in cell lines and normal tissues. *P < 0.05, **P < 0.01, ***P < 0.001.