Research Paper Volume 11, Issue 14 pp 5008—5034

Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice

Figure 2. Rb1 increases GABAARα1 and gephyrin expression in normal or MPP+-treated SH-SY5Y cell. (A) Effect of different concentrations of MPP+ on the expression of GABAARα1, GAD67, gephyrin, and PSD-95 in SH-SY5Y cell. (B) Effect of different concentrations of Rb1 on the expression of GABAARα1, GAD67, gephyrin, and PSD-95 in SH-SY5Y cell. (C) Effect of different concentrations of Rb1 on the expression of GABAARα1, gephyrin, and vGAT in 500 μM MPP+-treated SH-SY5Y cell. n = 3. Results are expressed as the mean ± SEM. **P < 0.01 and *P < 0.05 vs. control; ##P < 0.01 and #P < 0.05 vs. MPP+ group. Statistical significance was determined by one-way ANOVA and the Bonferroni post-hoc test for pairwise comparisons.