Research Paper Volume 11, Issue 14 pp 5008—5034

Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice

Figure 4. Rb1 modulates GABAergic transmission in the PFC in MPTP-treated mice. (A) Representative traces of GABA receptor-mediated mIPSCs. All mIPSCs were recorded at a holding potential of −65 mV. (B) Cumulative frequency plots of the inter-event interval (left) and quantitative analysis of the frequency of GABA receptor-mediated mIPSCs (right). (C) Cumulative frequency plots of mIPSC amplitude (left) and quantitative analysis of the amplitude of GABA receptor-mediated mIPSCs (right). (D) Representative traces of eIPSCs at 40, 60, and 100 μA stimulus intensities (top) and stimulus-response curves of PFC neurons from the indicated treatment groups (bottom). (E) Paired-pulse ratio analysis. Representative traces (top) and quantification analysis (bottom). Data were obtained from the whole-cell recordings of the prefrontal cortex pyramidal neurons from the three groups of mice including Ctrl mice, MPTP-treated mice, MPTP+Rb1 treated mice. n = 14–20 per group. Results are expressed as the mean ± SEM. **P < 0.01 and *P < 0.05 vs. control group; ##p < 0.01, #p < 0.05 vs. MPTP group. Statistical significance was determined by one-way ANOVA and Bonferroni test as post hoc comparisons.