**Figure 6.** **Effect of AK005401 on target proteins expressions.** Mice and HT22 cells were used to establish I/R model and OGD/R model, respectively. The expression levels of YY1, FGF21, PI3K, Akt, caspase 3, Bcl-2, and Bax were visualized using chemiluminescence method. As shown in Figure 6, (**A**) represents Western blots in panel (1, 2, 3, and 4 represent sham, I/R, AK005401siRNA, and NC, respectively). (**A1–A6**) represent the relative expressions of YY1, FGF21, PI3K, Akt, caspase 3, and the relative ratio of Bax/Bcl-2 in hippocampus tissue, respectively. As shown in Figure 6-2, (**B**) represents Western blots in panel (1, 2, 3, and 4 represent control, OGD/R, AKsiRNA, and NC, respectively). (**B1–B6**) represent the relative expressions of YY1, FGF21, PI3K, Akt, caspase 3, and the relative ratio of Bax/Bcl-2 in HT22 cells, respectively. Data were presented as mean±SD (n = 3). One-way ANOVA test was used to determine statistical significance. ^{*}*P* < 0.05 or ^{**}*P* < 0.01 vs. sham group or control group, ^{##}*P* < 0.01 vs. I/R group or OGD/R group.