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Research Paper Volume 11, Issue 14 pp 5192—5205

Down-regulation of lncRNA MALAT1 alleviates vascular lesion and vascular remodeling of rats with hypertension

Figure 7. Down-regulated MALAT1 and inhibited Notch-1 relieve pathological lesion of thoracic aorta. (A) thoracic aorta tissues of rats were observed using HE staining (× 500, scale bar: 20 μm); (B) medial thickness and lumen diameter in thoracic aorta of rats and their ratio; (C) ultrastructure of thoracic aorta of rats were observed by a transmission electron microscopy (× 10000, scale bar: 1 μm). * P < 0.05 vs the Con group; # P < 0.05 vs the AngII + si-Con group; & P < 0.05 vs the AngII + DMSO group; n = 10, data were expressed as mean ± standard deviation; one-way ANOVA was used for analyzing data, pairwise comparison was analyzed by Tukey’s post hoc test.