Research Paper Volume 11, Issue 14 pp 5192—5205

Down-regulation of lncRNA MALAT1 alleviates vascular lesion and vascular remodeling of rats with hypertension

Figure 8. Down-regulated MALAT1 and inhibited Notch-1 alleviate vascular fibrosis. (A) thoracic aorta fibrosis was observed using Masson staining (× 40, scale bar: 250 μm); (B) expression of collagen-I, collagen-III and Fibronectin mRNA in thoracic aorta tissues of rats detected by RT-qPCR; (C) protein bands of collagen-I, collagen-III and Fibronectin in thoracic aorta tissues of rats; (D) expression of collagen-I, collagen-III and Fibronectin in thoracic aorta tissues of rats detected by western blot analysis; * P < 0.05 vs the Con group; # P < 0.05 vs the AngII + si-Con group; & P < 0.05 vs the AngII + DMSO group; n = 10, data were expressed as mean ± standard deviation; one-way ANOVA was used for analyzing data, pairwise comparison was analyzed by Tukey’s post hoc test.