Research Paper Volume 11, Issue 14 pp 5192—5205

Down-regulation of lncRNA MALAT1 alleviates vascular lesion and vascular remodeling of rats with hypertension

Figure 9. Down-regulated MALAT1 and inhibited Notch-1 suppress apoptosis of aortic endothelial cells. (A) endothelial cells of thoracic aorta were observed by TUNEL staining (× 200, scale bar: 50 μm); (B) apoptosis index of endothelial cells in thoracic aorta; (C) protein bands of Bax and Bcl-2 of thoracic aorta tissues; (D) expression of Bax and Bcl-2 in thoracic aorta; * P < 0.05 vs the Con group; # P < 0.05 vs the AngII + si-Con group; & P < 0.05 vs the AngII + DMSO group; n = 10, data were expressed as mean ± standard deviation; one-way ANOVA was used for analyzing data, pairwise comparison was analyzed by Tukey’s post hoc test.