Research Paper Volume 11, Issue 14 pp 5215—5231

Profiling of mRNA of interstitial fibrosis and tubular atrophy with subclinical inflammation in recipients after kidney transplantation

Figure 5. IRF8 as the identification of IFTA-I between IFTA. (A) IRF8 expression had significant differences among the STA, IFTA and IFTA-I groups; ROC curve showed that IRF8 could be used for predicting IFTA-I from STA (B) and IFTA (C) and STA from IFTA (D); (E) All biopsies were divided into IRF8 high-expressed and low-expressed group and it indicated that recipients with high IRF8 expression were easier to develop into renal graft dysfunction and failure than that in the IRF8 low-expressed group (P < 0.00001); (F) AUC of IRF8 was 0.75 in the biopsies without rejection; (G) IRF8 expression was higher-expressed in the peripheral blood lymphocyte (PBL) in renal dysfunction w/o rejection than those with normal kidney function or with acute rejection in post-transplantation recipients. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.