Research Paper Volume 11, Issue 19 pp 8068—8084

A circular RNA from APC inhibits the proliferation of diffuse large B-cell lymphoma by inactivating Wnt/β-catenin signaling via interacting with TET1 and miR-888

Figure 7. Circ-APC is a promising diagnostic and prognostic biomarker in DLBCL. (A) qRT-PCR analysis of circ-APC expression in 80 pairs of DLBCL and adjacent normal tissues. (B) qRT-PCR analysis of circ-APC expression in plasma from 16 healthy controls and 27 DLBCL patients. (C) Receiver operating characteristic curve analysis on the diagnostic utility of plasma circ-APC in DLBCL. (D) Kaplan-Meier plot displaying patients’ overall survival based on the median circ-APC level in 80 DLBCL tissues. (E, F) qRT-PCR analysis of APC expression in DLBCL cell lines and tissues. (G) The correlation between circ-APC and APC expression in DLBCL tissues. **p < 0.01, ***p < 0.001.