Volume 11, Issue 19

15 October, 2019
pp 8036—8729

About the Cover

The cover features Figure 1 "Potential risk vs benefits of rapamycin-based anti-aging therapy" from Blagosklonny

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Table of Contents

Editorials

Mitochondrial fission and stemness in prostate cancer

Gianluca Civenni, Giuseppina M. Carbone, Carlo V. Catapano,

https://doi.org/10.18632/aging.102339 pp 8036—8038

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Damaged DNA marching out of aging nucleus

Nir Hacohen, Yuk Yuen Lan,

https://doi.org/10.18632/aging.102340 pp 8039—8040

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Intramembrane proteases protect from atherosclerosis

Torben Mentrup, Bernd Schröder,

https://doi.org/10.18632/aging.102342 pp 8041—8043

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GPR109A activation and aging liver

Ravirajsinh N. Jadeja, Pamela M. Martin,

https://doi.org/10.18632/aging.102343 pp 8044—8045

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Telomere clustering drives ALT

Jaewon Min, Jerry W. Shay,

https://doi.org/10.18632/aging.102369 pp 8046—8047

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Research Perspective

Rapamycin for longevity: opinion article

Mikhail V. Blagosklonny,

https://doi.org/10.18632/aging.102355 pp 8048—8067

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Research Papers

A circular RNA from APC inhibits the proliferation of diffuse large B-cell lymphoma by inactivating Wnt/β-catenin signaling via interacting with TET1 and miR-888

Yanping Hu, Yixun Zhao, Chao Shi, Pengfei Ren, Bing Wei, Yongjun Guo, Jie Ma,

https://doi.org/10.18632/aging.102122 pp 8068—8084

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Oxidative stress-induced cellular senescence desensitizes cell growth and migration of vascular smooth muscle cells through down-regulation of platelet-derived growth factor receptor-beta

Chun-Hsu Pan, Chang-Jui Chen, Chun-Ming Shih, Ming-Fu Wang, Jie-Yu Wang, Chieh-Hsi Wu,

https://doi.org/10.18632/aging.102270 pp 8085—8102

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Disulfiram suppressed ethanol promoted RANKL-induced osteoclastogenesis in vitro and ethanol-induced osteoporosis in vivo via ALDH1A1-NFATc1 axis

Yewei Jia, Jiawei Jiang, Kangxian Zhao, Tan Zhang, Peng Sun, Jiaxuan Peng, Qichang Yang, Yu Qian,

https://doi.org/10.18632/aging.102279 pp 8103—8119

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The interaction between STAT3 and nAChRα1 interferes with nicotine-induced atherosclerosis via Akt/mTOR signaling cascade

Shuang Xu, Huaner Ni, Hangwei Chen, Qiuyan Dai,

https://doi.org/10.18632/aging.102296 pp 8120—8138

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Hypermethylated long noncoding RNA MEG3 promotes the progression of gastric cancer

Lei Ding, Yuan Tian, Ling Wang, Miaomiao Bi, Dengke Teng, Sen Hong,

https://doi.org/10.18632/aging.102309 pp 8139—8155

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Knockdown of CREB3 activates endoplasmic reticulum stress and induces apoptosis in glioblastoma

Yaxin Hu, Liangzhao Chu, Jian Liu, Lei Yu, Shi-bin Song, Hua Yang, Feng Han,

https://doi.org/10.18632/aging.102310 pp 8156—8168

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KCNK levels are prognostic and diagnostic markers for hepatocellular carcinoma

Wen-Chao Li, Zhi-Yong Xiong, Pin-Zhu Huang, Yang-Jing Liao, Quan-Xi Li, Zhi-Cheng Yao, Ya-Di Liao, Shi-Lei Xu, Hui Zhou, Qing-Liang Wang, He Huang, Peng Zhang, Ji-Zong Lin, Bo Liu, Jie Ren, Kun-Peng Hu,

https://doi.org/10.18632/aging.102311 pp 8169—8182

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CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression

Yang Su, Xiurui Lv, Wei Yin, Lingling Zhou, Yilin Hu, Ang Zhou, FuZhen Qi,

https://doi.org/10.18632/aging.102312 pp 8183—8203

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SNHG22 overexpression indicates poor prognosis and induces chemotherapy resistance via the miR-2467/Gal-1 signaling pathway in epithelial ovarian carcinoma

Peng-Fei Zhang, Jing Wu, Jin-Hong Luo, Ke-Sang Li, Fei Wang, Wei Huang, Yin Wu, Shui-Ping Gao, Xue-Mei Zhang, Peng-Nan Zhang,

https://doi.org/10.18632/aging.102313 pp 8204—8216

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Association between bone mineral density and brain parenchymal atrophy and ventricular enlargement in healthy individuals

In-Suk Bae, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Myung-Hoon Han,

https://doi.org/10.18632/aging.102316 pp 8217—8238

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The long non-coding RNA, urothelial carcinoma associated 1, promotes cell growth, invasion, migration, and chemo-resistance in glioma through Wnt/β-catenin signaling pathway

Beilin Zhang, Shaokuan Fang, Yingying Cheng, Chunkui Zhou, Fang Deng,

https://doi.org/10.18632/aging.102317 pp 8239—8253

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Soluble klotho regulates the function of salivary glands by activating KLF4 pathways

Nguyen Chi Tai, Soo-A Kim, Sang-Gun Ahn,

https://doi.org/10.18632/aging.102318 pp 8254—8269

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Systematic profiling of alternative splicing events and splicing factors in left- and right-sided colon cancer

Xiaoliang Huang, Jungang Liu, Xianwei Mo, Haizhou Liu, Chunyin Wei, Lingxu Huang, Jianhong Chen, Chao Tian, Yongsheng Meng, Guo Wu, Weishun Xie, Franco Jeen P.C., Zujun Liu, Weizhong Tang,

https://doi.org/10.18632/aging.102319 pp 8270—8293

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β-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis

Dong Fu, Peng Li, Qingfeng Sheng, Zhibao Lv,

https://doi.org/10.18632/aging.102320 pp 8294—8312

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LncRNAs down-regulate Myh1, Casr, and Mis18a expression in the Substantia Nigra of aged male rats

Guoliang Zhang, Yunxiao Kang, Xu Feng, Rui Cui, Qiqing Guo, Xiaoming Ji, Yuanxiang Huang, Yannan Ma, Shufeng Liu, Geming Shi,

https://doi.org/10.18632/aging.102321 pp 8313—8328

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Involvement of adiponectin in age-related increases in tear production in mice

Yosuke Shikama, Mie Kurosawa, Masae Furukawa, Naozumi Ishimaru, Kenji Matsushita,

https://doi.org/10.18632/aging.102322 pp 8329—8346

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Gomisin M2 from Baizuan suppresses breast cancer stem cell proliferation in a zebrafish xenograft model

Yeguo Yang, Erwei Hao, Xianglong Pan, Dechao Tan, Zhengcai Du, Jinling Xie, Xiaotao Hou, Jiagang Deng, Kun Wei,

https://doi.org/10.18632/aging.102323 pp 8347—8361

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Mogroside V protects porcine oocytes from in vitro ageing by reducing oxidative stress through SIRT1 upregulation

Junyu Nie, Lumin Sui, Huiting Zhang, Hengye Zhang, Ke Yan, Xiaogan Yang, Shengsheng Lu, Kehuan Lu, Xingwei Liang,

https://doi.org/10.18632/aging.102324 pp 8362—8373

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LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis

Dong Fu, Chunwen Lu, Xingzhou Qu, Peng Li, Kai Chen, Liancheng Shan, Xiaodong Zhu,

https://doi.org/10.18632/aging.102325 pp 8374—8385

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Cognitive impairment and transcriptomic profile in hippocampus of young mice after multiple neonatal exposures to sevoflurane

Shao-Yong Song, Xiao-Wen Meng, ZhengYuan Xia, Hong Liu, Juan Zhang, Qing-Cai Chen, Hua-Yue Liu, Fu-Hai Ji, Ke Peng,

https://doi.org/10.18632/aging.102326 pp 8386—8417

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mTORC1-Sch9 regulates hydrogen sulfide production through the transsulfuration pathway

Zhou Lyu, Xuejie Gao, Weiyan Wang, Jinye Dang, Li Yang, Mengli Yan, Shah Arman Ali, Yang Liu, Binghua Liu, Meng Yu, Linfang Du, Ke Liu,

https://doi.org/10.18632/aging.102327 pp 8418—8432

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Brain pyrimidine nucleotide synthesis and Alzheimer disease

Alba Pesini, Eldris Iglesias, M.Pilar Bayona-Bafaluy, Nuria Garrido-Pérez, Patricia Meade, Paula Gaudó, Irene Jiménez-Salvador, Pol Andrés-Benito, Julio Montoya, Isidro Ferrer, Pedro Pesini, Eduardo Ruiz-Pesini,

https://doi.org/10.18632/aging.102328 pp 8433—8462

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Effect of age as a continuous variable on survival outcomes and treatment selection in patients with extranodal nasal-type NK/T-cell lymphoma from the China Lymphoma Collaborative Group (CLCG)

Wei-Xin Liu, Mei Shi, Hang Su, Ying Wang, Xia He, Li-Ming Xu, Zhi-Yong Yuan, Li-Ling Zhang, Gang Wu, Bao-Lin Qu, Li-Ting Qian, Xiao-Rong Hou, Fu-Quan Zhang, Yu-Jing Zhang, Yuan Zhu, Jian-Zhong Cao, Sheng-Min Lan, Jun-Xin Wu, Tao Wu, Su-Yu Zhu, Shu-Nan Qi, Yong Yang, Bo Chen, Ye-Xiong Li,

https://doi.org/10.18632/aging.102331 pp 8463—8473

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The prognostic value of major facilitator superfamily domain-containing protein 2A in patients with hepatocellular carcinoma

Shan Xing, Jun Kan, Aishan Su, Qiao-Dan Liu, Kailin Wang, Xiuyu Cai, Jun Dong,

https://doi.org/10.18632/aging.102333 pp 8474—8483

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CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma

Rongjie Zhao, Junjie Ni, Si Lu, Sujing Jiang, Liangkun You, Hao Liu, Jiawei Shou, Chongya Zhai, Wei Zhang, Shengpeng Shao, Xinmei Yang, Hongming Pan, Weidong Han,

https://doi.org/10.18632/aging.102334 pp 8484—8501

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Albumin infusion may decrease the incidence and severity of overt hepatic encephalopathy in liver cirrhosis

Zhaohui Bai, Mauro Bernardi, Eric M. Yoshida, Hongyu Li, Xiaozhong Guo, Nahum Méndez-Sánchez, Yingying Li, Ran Wang, Jiao Deng, Xingshun Qi,

https://doi.org/10.18632/aging.102335 pp 8502—8525

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Ninjurin 2 overexpression promotes human colorectal cancer cell growth in vitro and in vivo

Gang Li, Li-Na Zhou, Han Yang, Xixi He, Yuxia Duan, Fang Wu,

https://doi.org/10.18632/aging.102336 pp 8526—8541

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Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice

Jin-Lan Huang, Chao Yu, Min Su, Si-Man Yang, Fan Zhang, Yuan-Yuan Chen, Jin-Yuan Liu, Yi-Fan Jiang, Zhen-Guo Zhong, Deng-Pan Wu,

https://doi.org/10.18632/aging.102337 pp 8542—8555

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Conserved aging-related signatures of senescence and inflammation in different tissues and species

Emanuel Barth, Akash Srivastava, Milan Stojiljkovic, Christiane Frahm, Hubertus Axer, Otto W. Witte, Manja Marz,

https://doi.org/10.18632/aging.102345 pp 8556—8572

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High body mass index, brain metabolism and connectivity: an unfavorable effect in elderly females

Arianna Sala, Maura Malpetti, Anna Ferrulli, Luigi Gianolli, Livio Luzi, Daniela Perani, Alzheimer’s Disease Neuroimaging Initiative (ADNI) database,

https://doi.org/10.18632/aging.102347 pp 8573—8586

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A molecular sub-cluster of colon cancer cells with low VDR expression is sensitive to chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors treatment

Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang, Hua Cao,

https://doi.org/10.18632/aging.102349 pp 8587—8603

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Tryptophan metabolite 5-methoxytryptophan ameliorates arterial denudation-induced intimal hyperplasia via opposing effects on vascular endothelial and smooth muscle cells

Chung-Huang Chen, Yen-Chun Ho, Hua-Hui Ho, Li-Yu Liang, Wei-Cheng Jiang, Guan-Lin Lee, Jen-Kuang Lee, Yu-Juei Hsu, Cheng-Chin Kuo, Kenneth K. Wu, Shaw-Fang Yet,

https://doi.org/10.18632/aging.102350 pp 8604—8622

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TRIM59 loss in M2 macrophages promotes melanoma migration and invasion by upregulating MMP-9 and Madcam1

Yuan Tian, Yantong Guo, Pei Zhu, Dongxu Zhang, Shanshan Liu, Mengyan Tang, Yuanxin Wang, Zheng Jin, Dong Li, Dongmei Yan, Guiying Li, Xun Zhu,

https://doi.org/10.18632/aging.102351 pp 8623—8641

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Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease

Qiang Gao, Yuan Wang, Xin Wang, Shuang Fu, Xin Zhang, Rui-Tao Wang, Xin Zhang,

https://doi.org/10.18632/aging.102352 pp 8642—8663

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Decreased RIPK1 expression in chondrocytes alleviates osteoarthritis via the TRIF/MyD88-RIPK1-TRAF2 negative feedback loop

Shuang Liang, Zheng-Gang Wang, Zhen-Zhen Zhang, Kun Chen, Zheng-Tao Lv, Yu-Ting Wang, Peng Cheng, Kai Sun, Qing Yang, An-Min Chen,

https://doi.org/10.18632/aging.102354 pp 8664—8680

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The prognostic value of YAP1 on clinical outcomes in human cancers

Ying Wu, Yanshen Hou, Peng Xu, Yujiao Deng, Kang Liu, Meng Wang, Tian Tian, Cong Dai, Na Li, Qian Hao, Dingli Song, Ling hui Zhou, Zhijun Dai,

https://doi.org/10.18632/aging.102358 pp 8681—8700

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Time-to-event analyses of lower-limb venous thromboembolism in aged patients undergoing lumbar spine surgery: a retrospective study of 1620 patients

Liang Li, Zhaohui Li, Yachong Huo, Dalong Yang, Wenyuan Ding, Sidong Yang,

https://doi.org/10.18632/aging.102364 pp 8701—8709

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Association of a novel seven-gene expression signature with the disease prognosis in colon cancer patients

Haojie Yang, Hua Liu, Hong-Cheng Lin, Dan Gan, Wei Jin, Can Cui, Yixin Yan, Yiming Qian, Changpeng Han, Zhenyi Wang,

https://doi.org/10.18632/aging.102365 pp 8710—8727

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Correction

Correction for: Real-world effectiveness of medications on survival in patients with COPD-heart failure overlap

Vincent Yi-Fong Su, Yao-Hsu Yang, Diahn-Warng Perng, Ying-Huang Tsai, Kun-Ta Chou, Kang-Cheng Su, Wei-Juin Su, Pau-Chung Chen, Kuang-Yao Yang,

https://doi.org/10.18632/aging.102363 pp 8728—8729

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