Research Paper Volume 11, Issue 17 pp 6638—6656

Dlx5 and Dlx6 expression in GABAergic neurons controls behavior, metabolism, healthy aging and lifespan

Figure 4. Behavioral response in an open field test. (A) Travel pathway (red) of illustrative examples of control, VgatΔDlx5-6/+ and VgatΔDlx5-6 mice (ΔDlx5-6/+ and ΔDlx5-6 respectively) filmed for 10 min in the open field test arena (72x72 cm larger square perimeter). The central region (36x36 cm) is indicated by the smaller square. VgatΔDlx5-6/+ and VgatΔDlx5-6 animals travelled a significantly longer distance than their control littermates (B) and spent more time in the center of the open field (C), where they entered more rapidly (D) and more frequently (E). Histograms bars indicate the mean±SEM; One way ANOVA, post hoc analysis by Tukey’s HSD (Controls: n = 45 and VgatΔDlx5-6/+: n = 38, VgatΔDlx5-6 : n=34): ***: p<0.001; **: p<0.01; *: p<0.05.