Figure 5. Mouse velocity and acceleration in an open field test. Maximal (A) and average (B) velocity and maximal acceleration (C) of mice in the open field test (see Figure 2). During the 10 minutes test the velocity and acceleration of mutant mice was significantly higher than that of controls. (D) Locomotor activity was measured on a 90 min period in a circular corridor for three consecutive days. Only the first day a significant difference was observed suggesting an increased response to novelty of mutant mice. One way (A, B, C) and repeated two way (D) ANOVA tests, Bonferroni post-hoc test p<0.01 were performed. Histograms bars indicate the mean±SEM. **: p<0.01; *: p<0.05.