<i>Dlx5</i> and <i>Dlx6</i> expression in GABAergic neurons controls behavior, metabolism, healthy aging and lifespan

Camille de Lombares; Eglantine Heude; Gladys Alfama; Anastasia Fontaine; Rim Hassouna; Cécile Vernochet; Fabrice de Chaumont; Christophe Olivo-Marin; Elodie Ey; Sébastien Parnaudeau; François Tronche; Thomas Bourgeron; Serge Luquet; Giovanni Levi; Nicolas Narboux-Nême

doi:doi:10.18632/aging.102141

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Research Paper Volume 11, Issue 17 pp 6638—6656

Dlx5 and Dlx6 expression in GABAergic neurons controls behavior, metabolism, healthy aging and lifespan

Figure 7. Reduced weight and adipose tissue in Vgat^ΔDlx5-6/+ and Vgat^ΔDlx5-6 mice. (A) The body weight of a cohorts of female control, Vgat^ΔDlx5-6/+ and Vgat^ΔDlx5-6 mice (n ≥ 8 per group) was measured during the first 20 months of aging. At all time points analyzed Vgat^ΔDlx5-6/+ and Vgat^ΔDlx5-6 mice (male (Supplementary Figure 7) and female) presented a highly significant weight reduction. (B–D) Gross anatomical inspection (B), MRI analysis (C) and dissected organ weight (D) confirmed a dramatic reduction of visceral and subcutaneous WAT and of BAT in Vgat^ΔDlx5-6 mice (n=11 controls, n=7 Vgat^ΔDlx5-6). Mann-Witney test; ***: p<0.001; **: p<0.01; *: p<0.05.