Figure 7. Reduced weight and adipose tissue in VgatΔDlx5-6/+ and VgatΔDlx5-6 mice. (A) The body weight of a cohorts of female control, VgatΔDlx5-6/+ and VgatΔDlx5-6 mice (n ≥ 8 per group) was measured during the first 20 months of aging. At all time points analyzed VgatΔDlx5-6/+ and VgatΔDlx5-6 mice (male (Supplementary Figure 7) and female) presented a highly significant weight reduction. (B–D) Gross anatomical inspection (B), MRI analysis (C) and dissected organ weight (D) confirmed a dramatic reduction of visceral and subcutaneous WAT and of BAT in VgatΔDlx5-6 mice (n=11 controls, n=7 VgatΔDlx5-6). Mann-Witney test; ***: p<0.001; **: p<0.01; *: p<0.05.