Research Paper Volume 11, Issue 16 pp 5924—5942

Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus

Figure 4. Heart failure (HF) rats display similar reference spatial memory compared to control rats. (A) Representative cartoon showing the rat and platform position in the pool. (B) Representative trajectory heat maps obtained from one Sham rat and one HF rat during Water Maze test between day 5 and day 8. Pseudocolor intensity indicates the time latency that the rat remained swimming in the pool searching for the platform. HF rats spends more time searching the platform in day 5; however, this behavior was absent in day 8. (C) Summary data showing that at day 5 HF rats need more time to find the platform; however, this effect was absent at day 8. (D) Summary data showing mean distance travelled during day 5 and day 8. At day 5 HF rats travel more distance compared to Sham animals. No significant differences in traveled distance was found between groups at day 8. (E, F) Sham and HF rats display similar path efficiency and speed in day 5 and day 8 of the test. #, p<0.05 vs. Sham day 5; two-way ANOVA following Holm Sidak test. n=6 rats per group.