Research Paper Volume 11, Issue 16 pp 5924—5942

Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus

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Figure 8. HF rats display alterations in the Wnt signaling pathway in the hippocampus. (A) Representative immunoblots showing the expression levels of active β-catenin, total GSK-3β and the inhibited form of GSK-3β (phospho-Ser9) in hippocampus micro-punches obtained from Sham rats and HF rats. (B) Summary data showing densitometric analysis of β-catenin, (C) total GSK-3β (D) and p-GSK-3β normalized against housekeeping protein GAPDH. Values are means ± S.E.M. *, p<0.05, Unpaired t-test. n=6 rats per group.