Research Paper Volume 11, Issue 16 pp 5943—5974

Discovering markers of healthy aging: a prospective study in a Danish male birth cohort

Figure 2. The significance of associations between each cognitive measure and all (other) non-IDP variables. The Manhattan plot shows all results for 31 cognitive variables against each of the 39 (other) non-IDPs (1209 values) adjusted for confounders: age, motion, and head size. Significance is plotted as -log 10 p-values, arranged by cognitive variables on the x-axis, multiple testing thresholds across all pairwise associations are marked with a horizontal line, FWE top line and FDR bottom line (FWE threshold: 4.38 x 10-4; FDR threshold: 3.82 x 10-3). All other non-IDPs are distinguished by plotting color (demographic = yellow, health = red, lifestyle = blue). (Abbreviations: IQ-11, IQ-20, IQ-57, IQ-63 = general intelligence scores at ages 11, 20, 57, and 63; MOT = motor task; ME = mean error; ML = mean latency; PAL = paired associates learning; TE adjusted = total errors adjusted; TT Adjusted = total trials adjusted; PRM = pattern recognition memory; SD = standard deviation; CL = correct latency; RTI = reaction time task; MT = movement time; RT = reaction time; RVP = rapid visual processing task; MLB1-4 = mean latency block 1 to 4; SOC = Stockings of Cambridge task; Mean Initial TT 5 Moves = mean initial total time 5 moves task; Mean Subse TT 5 Moves = mean subsequent thinking time 5 moves task; SRM = spatial recognition memory; TM = trail making task).