Research Paper Volume 11, Issue 16 pp 5975—5991

LINC00511 promotes the malignant phenotype of clear cell renal cell carcinoma by sponging microRNA-625 and thereby increasing cyclin D1 expression


Figure 1. LINC00511 is upregulated in ccRCC tissues and cell lines. (A) RT-qPCR analysis was conducted to quantitate the expression of LINC00511 in 49 pairs of ccRCC samples and matched adjacent normal renal tissue samples. *P < 0.05 vs. normal renal tissues. (B) Relative LINC00511 expression in four ccRCC cell lines (A498, 786-O, ACHN, and Caki-2) and one normal human renal cell line (HK-2) was quantified by RT-qPCR. *P < 0.05 vs. HK-2 cells. (C) The overall survival of patients with ccRCC harboring low or high LINC00511 levels was studied by Kaplan–Meier survival analysis, and the curves were compared by the logrank test. P = 0.035.