Research Paper Volume 11, Issue 16 pp 5992—6013

LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts

Figure 1. UVB up-regulated RP11-670E13.6 levels, and knockdown of RP11-670E13.6 promoted cellular senescence. (A) Schematic diagram of the localization of RP11-670E13.6. (B) Expression of RP11-670E13.6 in the UVB irradiation and control groups, as determined by qRT-PCR. Data are shown as the means ± standard errors of the means based on at least three independent experiments. (C) (a) UVB irradiation decreased the mean length of telomeres in HDFs at 24 h post-irradiation. (b) Knockdown of RP11-670E13.6 decreased the mean length of telomeres in HDFs at 24 h post-irradiation. Data are shown as the means ± standard errors of the means based on at least three independent experiments. P values were determined by Student’s t-tests. *P < 0.05; **P < 0.01; and ***P < 0.001.