Research Paper Volume 11, Issue 16 pp 6053—6068

LINC01198 promotes proliferation and temozolomide resistance in a NEDD4-1-dependent manner, repressing PTEN expression in glioma

Figure 1. LINC01198 is overexpressed in human glioma. (A) Expression level of LINC01198 was determined and normalized to GAPDH in 90 pairs of glioma tissues and their corresponding adjacent normal tissues by qRT-PCR. (B) The patients were divided into the tumor size ≤3 cm and tumor size >3 cm groups. The diagram shows the LINC01198 expression in each group. P = 0.001. (C) The patients were divided into the stage I-II and III-IV groups. The diagram shows the LINC01198 expression in each group. P = 0.006. (D and E) Glioma patients were divided into the LINC01198High group and LINC01198Low group according to the result of qRT-PCR. Survival and recurrence curves were constructed using the log-rank test. The results show the OS and recurrence for glioma patients with high LINC01198 expression and those with low LINC01198 expression.