Research Paper Volume 11, Issue 16 pp 6120—6133

MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice

Figure 7. Proposed model for this study. MiR-181a is downregulated during AD development via an unknown mechanism. Normally, miR-181a targets and suppresses FOXO1, one positive regulator of pericyte apoptosis, which induces BBB breakdown and AD development, manifesting cognitive deficits and amyloid plaque deposition. Thus, this feedback regulation may accelerate AD development.