Research Paper Volume 11, Issue 16 pp 6134—6152

Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity

Figure 2. Effect of different concentrations of amyloid peptides on the proteolytic activity of the Arg/N-end rule pathway. Degradation of 35S-methionine labeled Asp609-PTPRNf in the presence of Aβ42 (A) or H6R-Aβ42 (B) was assayed as described in the legend to Figure 1B. (C) – quantification of (A) and (B) at 60 min chase (Aβ42 – black squares, H6R-Aβ42 – red circles). Each value is the mean expressed as a percentage of the level of Asp609-PTPRNf at 0 min chase ± SD of at least three independent experiments.