Research Paper Volume 11, Issue 16 pp 6134—6152

Figure 2. Effect of different concentrations of amyloid peptides on the proteolytic activity of the Arg/N-end rule pathway. Degradation of ³⁵S-methionine labeled Asp₆₀₉-PTPRN^f in the presence of Aβ₄₂ (A) or H6R-Aβ₄₂ (B) was assayed as described in the legend to Figure 1B. (C) – quantification of (A) and (B) at 60 min chase (Aβ₄₂ – black squares, H6R-Aβ₄₂ – red circles). Each value is the mean expressed as a percentage of the level of Asp₆₀₉-PTPRN^f at 0 min chase ± SD of at least three independent experiments.