Research Paper Volume 11, Issue 16 pp 6134—6152

Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity

Figure 3. Interaction of Aβ42, tRNA, and Ate1. Schematic representation of ELISA assay with immobilized anti-Aβ1-17 antibodies (A) or anti-Aβ36-42 antibodies (B). (C) Detection of tRNA and Ate1 ability to interact with C-terminus of Aβ. (D) Same as (C) but with N-terminal region of Aβ. OD450 – optical density measured at 450 nm. Each value is the mean ± SD of at least four independent experiments; *p < 0.04, **p < 0.01, ***p < 0.001.