Research Paper Volume 11, Issue 16 pp 6199—6216

Attenuated BK channel function promotes overactive bladder in a rat model of obesity

Figure 2. HFD feeding successfully induces detrusor overactivity. (A) Representative cystometrogram illustrating the changes in bladder function in HFD rats. A lower bladder capacity (B), smaller voiding volume (C), shorter voiding interval (E) and higher frequency of non-voiding contractions (F) were recorded in HFD rats than in ND animals. However, the maximum pressure during voiding did not differ significantly between the groups. Data are expressed as the mean ± SEM, N = 10 per group, * P < 0.05 for ND vs. HFD. ND: normal diet; HFD: high-fat diet; NS: not significant; NVCs: non-voiding contractions. Arrow indicates the voiding peak.