Figure 2. HFD feeding successfully induces detrusor overactivity. (A) Representative cystometrogram illustrating the changes in bladder function in HFD rats. A lower bladder capacity (B), smaller voiding volume (C), shorter voiding interval (E) and higher frequency of non-voiding contractions (F) were recorded in HFD rats than in ND animals. However, the maximum pressure during voiding did not differ significantly between the groups. Data are expressed as the mean ± SEM, N = 10 per group, * P < 0.05 for ND vs. HFD. ND: normal diet; HFD: high-fat diet; NS: not significant; NVCs: non-voiding contractions. Arrow indicates the voiding peak.