Research Paper Volume 11, Issue 16 pp 6199—6216

Attenuated BK channel function promotes overactive bladder in a rat model of obesity

Figure 9. The inhibitory effects of NS1619 on EFS-induced contractions are attenuated in HFD DSM strips. Original recordings of DSM strips demonstrating the inhibitory effects of NS1619 (30 μM) on EFS-induced contractions (stimulation frequency 0.5-50 Hz) in the ND (A) and HFD (B) groups. The frequency response curves illustrate the differences in amplitude of EFS-induced contractions in the presence and absence of 30 μM NS1619 in ND (C) and HFD (D) DSM strips.(E) Summary data illustrating the inhibitory effects of 30 μM NS1619 on EFS-induced contractions at the highest stimulation frequency (50 Hz) in isolated DSM strips from both groups. Data are expressed as the mean ± SEM; n = 12, N = 7 in the ND group, n = 13, N = 7 in the HFD group; * P < 0.05 for ND vs. HFD; # P < 0.05 for control vs. NS1619. ND: normal diet; HFD: high-fat diet; NS: not significant.