Research Paper Volume 11, Issue 16 pp 6252—6272

Prognostic value of preoperative hematological markers combined with molecular pathology in patients with diffuse gliomas

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Figure 3.

Prognostic model combining molecular pathology and hematological markers for gliomas. (A) In the model, infiltrative gliomas include lower-grade gliomas and Grade IV glioma. Lower-grade gliomas are divided into 5 molecular groups with different OS. NLR is proposed to further stratify the OS of 4 of these groups (triple-positive tumors are excepted). In Grade IV glioma, high NLR independently predicts worse OS. (B) Kaplan-Meier OS curves of the 9 subgroups of lower-grade gliomas. The OS of the 9 subgroups are significantly different (P < 0.001). (C) Kaplan-Meier OS curves of the 4 risk groups in lower-grade gliomas: Subgroups 1, 2, and 4 were integrated into a Low risk group; Subgroups 3, 5, 6, and 8 were integrated into an Intermediate-I risk group; Subgroup 9 comprises the Intermediate-II risk group; and Subgroup 7 constitutes the High risk group. The OS of the 4 risk groups differs significantly (P < 0.001).