Research Paper Volume 11, Issue 16 pp 6252—6272

Prognostic value of preoperative hematological markers combined with molecular pathology in patients with diffuse gliomas

Figure 3. Prognostic model combining molecular pathology and hematological markers for gliomas. (A) In the model, infiltrative gliomas include lower-grade gliomas and Grade IV glioma. Lower-grade gliomas are divided into 5 molecular groups with different OS. NLR is proposed to further stratify the OS of 4 of these groups (triple-positive tumors are excepted). In Grade IV glioma, high NLR independently predicts worse OS. (B) Kaplan-Meier OS curves of the 9 subgroups of lower-grade gliomas. The OS of the 9 subgroups are significantly different (P < 0.001). (C) Kaplan-Meier OS curves of the 4 risk groups in lower-grade gliomas: Subgroups 1, 2, and 4 were integrated into a Low risk group; Subgroups 3, 5, 6, and 8 were integrated into an Intermediate-I risk group; Subgroup 9 comprises the Intermediate-II risk group; and Subgroup 7 constitutes the High risk group. The OS of the 4 risk groups differs significantly (P < 0.001).