Research Paper Volume 11, Issue 16 pp 6273—6285

Elevated kindlin-2 promotes tumour progression and angiogenesis through the mTOR/VEGFA pathway in melanoma

Figure 4. Kindlin-2 promotes tumour growth and lung metastasis in vivo. (A) SK28-shNC, SK28-sh-kindlin-2, A375-Vector and A375-kindlin-2 cells were subcutaneously inoculated to examine tumour growth ability (left); tumour growth curves of the subcutaneous xenografts were shown (right). (B) Lung metastasis was investigated with the metastasis model in vivo, and the number of metastases was examined by H&E staining. (C) Representative images from tumour serial sections stained with H&E and with kindlin-2 and CD31 antibodies by IHC. *p<0.05, **p<0.01.