Research Paper Volume 11, Issue 16 pp 6358—6370

Platelet activation in diabetic mice models: the role of vascular endothelial cell-derived protein disulfide isomerase-mediated GP IIb/IIIa receptor activation

Figure 4. PDI was carried by EMPs, and the contents of CD144-positive EMPs and EMP-PDI in the plasma were increased in the diabetic group. (A) The content of CD144-positive EMPs in the plasma of diabetic mice was increased; (B) Dual-color flow cytometry was used to show that PDI is carried by the particles in endothelial cells; (C) The content of EMP-PDI in the plasma of diabetic mice was increased;*P < 0.05, **P < 0.01, ***P < 0.001 versus Chow; #P < 0.05, ##P < 0.01, ###P < 0.001 versus Chow + Rutin; P < 0.05, ††P < 0.01, P < 0.001 versus DM. Chow, normal group; Chow + Rutin, normal diet plus rutin; DM, Diabetic group; DM + Rutin, diabetic group plus rutin (n = 5–11). Data were analyzed using one-way ANOVA.