Figure 1. Workflow diagram of the study design. First, transcriptomic profiles of 13 human brain regions were derived from GTEx dataset. Second, differential analysis was performed to investigate regional specific changes. Distributions and functional annotations of DAGs were analyzed subsequently. Finally, Co-expression analysis was performed in caudate and hippocampus to study core modules and hub genes. The volcano plot and heatmap were generated using random sampling data of caudate transcriptome.